A thorough examination of reaction conditions as well as the application of microwave radiation resulted in a highly effective and simple synthetic procedure offering C4-substituted pyrimidines with good yields to exceptional levels.
Short reaction time (15 min) and extremely low catalyst loading (0.5 mol%) are the main advantages of our tetrakis(triphenylphosphine)palladium(0) catalyzed microwave-assisted procedure, which could be used for quick and low-cost regioselective preparation of substituted pyrimidine rings. [2-4 dichloropyrimidine]